Definintions of Key Terms
Nutritional Baseline™: The complete and precise replenishment of all essential and conditionally essential nutrients, designed to restore full biological balance, drive natural energy production, and optimize the performance of every system in the body—establishing the foundation for long-term health and resilience.
Neo-Vitamins™: Essential, long-retention exogenous compounds that the human body cannot synthesize in sufficient quantity, if at all, and which are retained in tissues over extended periods (days to weeks or longer). These compounds play foundational, persistent roles in key physiological systems such as energy metabolism, cellular signaling, and organ integrity
BioSwitches™: Transient, short-retention bioactive compounds that temporarily modulate biological pathways through acute signaling, enzyme inhibition, or gene expression. They typically have short blood half-lives and minimal tissue retention, and are used to strategically “flip” pathway states—upregulating, downregulating, or modulating processes like detox, inflammation, senescence, or focus.
Expanded Definintions
Neo Vitamins™: Nutrients the body either cannot make or does not make in sufficient quantity, which:Are required for long-term structural or metabolic functions.Persist in the body or tissues (days to weeks).Are often retained or embedded in membranes, pigments, or antioxidant systems. Are used “as-is” by the body—not just to stimulate a pathway but to directly perform a function.Examples from your table:Lutein / Zeaxanthin / Lycopene – accumulate in the retina or fat tissues.CoQ10 – embedded in mitochondrial membranes.Spermidine / PQQ – have longer tissue retention and epigenetic influence.Ergothioneine – stored in mitochondria and bone marrow for extended periods.Taurine / Carnitine – persist and serve structural and metabolic roles.
BioSwitches™: Nutrients or compounds that:Trigger or modulate key biological pathways, such as NRF2, AMPK, or NF-κB.Have short to moderate half-lives (typically <24 hours).Are cleared quickly but leave behind longer-term cellular effects.Are best taken in pulses or cycles, not daily accumulation. Examples from your BioSwitch list (all validated):Sulforaphane – short half-life, activates NRF2, epigenetic impact.Apigenin, Berberine, EGCG, Curcumin, Fisetin, Luteolin, Naringenin, Hesperidin, Quercetin – all have <24hr plasma half-life, trigger signaling cascades, and do not persist.